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Resbiotic

resbiotic.com

Partners

Klaviyo®
Shopify Plus®

Industry

Wellness

Services

Email Marketing CRM Management

Partners

Klaviyo®
Shopify Plus®

How a Science-Backed Supplement Brand Fixed Its Email Foundation While Expanding Into Walmart, Running Clinical Trials, and Navigating GLP-1 Regulations

✅ Deliverability issues identified and addressed within the first month, starting with a welcome email open rate of just 37%
✅ Flow architecture rebuilt from scratch, replacing a system that never properly filtered browse abandonment, cart abandonment, and welcome series overlap
✅ Campaign conversion value increased 74% within the first two weeks of active campaign management
✅ Email attribution targeted from 20% toward the 30–40% range by fixing subscriber quality and inbox placement
✅ Spam complaint rate reduced through segment hygiene, frequency controls, and suppression of unengaged profiles
✅ Regulatory-compliant email system established for a supplement brand under active legal scrutiny around GLP-1 claims

01

Challenge

Challenge

Your product actually works. You have peer-reviewed research, clinical trials in progress, and a founder who’s a physician-scientist. You’re private equity-backed, expanding into Walmart, already in GNC, and growing toward $10–12 million in annual revenue across DTC, Amazon, and retail.

But your email program isn’t keeping up with any of it.

The welcome series has a 37% open rate on the first email—which means nearly two-thirds of new subscribers never see their first touchpoint. Deliverability is dragging. The flows your previous team set up never properly filtered overlapping sequences, so customers get hit with welcome emails, browse abandonment, and cart abandonment all at once. Revenue is almost entirely campaign-driven, with flows contributing next to nothing.

On top of that, you’re selling in one of the most regulated categories in e-commerce. Every claim needs an asterisk. You can’t use the word “weight” in your marketing. Competitors are getting sued over GLP-1 messaging—and GLP-1 content is exactly what your audience responds to most. Your in-house team is small, stretched thin, and about to go through a marketing leadership transition mid-engagement.

The email channel isn’t just underperforming. It’s a liability that’s about to get more complicated as retail doors open and the product line expands.

02

Strategy

Strategy

Deliverability Came First

Nothing else mattered if emails weren’t landing. The welcome series—the highest-intent touchpoint—was underperforming at 37%. Subscriber validation, pop-up optimization, and list hygiene became the foundation before any creative work started.

Retention.com was pulling in visitors who had never opted in, inflating the list with low-quality contacts. Leadership was pushing monthly full-list blasts that spiked spam complaints. Both needed to be addressed with data—showing exactly how each practice impacted deliverability scores so decisions about send strategy were informed, not emotional.

Flows Were Rebuilt Around Actual Customer Journeys

The existing flows had a fundamental problem: they didn’t talk to each other. A customer could enter the welcome series, trigger browse abandonment, and hit cart abandonment simultaneously. The filtering logic to prevent this had never been built.

A customer tagging system ensured people in one flow were excluded from others. No more stacking. No more over-discounting someone already in a welcome sequence. The transition was handled carefully—existing subscribers completed their current journeys while new subscribers entered the rebuilt flows—so nothing broke during the switchover.

Content Matched the Complexity of the Product

Gut health probiotics aren’t impulse purchases. Customers need to understand why this product is different, what the gut-lung axis is, how probiotics interact with prebiotics and postbiotics, and why the formulation matters. If the emails read like every other supplement brand pushing discount codes, they fail.

Campaigns split into three categories: product-focused emails for direct conversion, educational content for weekend sends when readers had time for longer material, and customer testimonial campaigns for social proof. A/B testing focused on click rate—CTA language, button placement, color—because getting clicks from an audience that needs education before they buy was the core challenge.

Regulatory Compliance Was Built Into the Workflow

Every email went through a structured review process: copy brief first, brand approval, then design. Asterisks and disclaimer superscripts were added to every claim—and in supplements, nearly everything is a claim. GLP-1 content, which consistently outperformed other subject lines, was handled with extra caution to avoid the legal exposure already hitting competitors.

This wasn’t just about checking boxes. The brand was actively running clinical trials requiring IRB approval. Healthcare practitioner flows were being developed for a separate gated audience of providers who needed scientifically precise communication. The email system had to support consumer marketing, regulatory compliance, and professional-grade content simultaneously.

Campaigns Aligned to Business Reality

The campaign calendar couldn’t follow a static content schedule. It had to adapt to inventory constraints (the best-selling ResV product was out of stock for weeks), retail launch timelines (Walmart on April 28th), seasonal promotions (Mother’s Day, Memorial Day), and a pending price change that affected discount strategy.

Store locator campaigns drove foot traffic to GNC and Walmart locations. Educational content from the in-house registered dietitian was repurposed into email. The calendar flexed around product availability rather than forcing promotions on products that couldn’t ship.

Results

Deliverability & List Health

  • Deliverability scores trended upward from the first month as list hygiene, suppression segments, and subscriber validation took effect
  • Spam complaint rate decreased through frequency controls and reduced full-list blasting
  • Suppression segments caught and excluded unengaged profiles before they could damage domain reputation

Campaign Performance

  • 74% increase in conversion value within the first two weeks of campaign management
  • Campaign cadence stabilized at two to three sends per week with consistent engagement
  • A/B testing program established across subject lines, CTA language, and send timing

Flow Architecture

  • Six primary flows rebuilt with proper exclusion logic and customer tagging
  • Flow overlap eliminated—customers no longer received welcome, browse, and cart emails simultaneously
  • Revenue mix began shifting from campaign-heavy toward automated flow contribution

Operational Outcomes

  • Copy review workflow balanced regulatory compliance with campaign velocity
  • Brand guidelines codified into the email design system: sentence case, no emojis in headers, no gradients, claim disclaimers on all copy
  • Smooth operational continuity maintained through a VP of Marketing transition mid-engagement

If you’re selling something that requires education, operates under regulatory scrutiny, and is scaling across retail channels at the same time—your email program can’t just send promotions. It has to be as sophisticated as the product itself.

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